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Home Health

Are Seed Oils Behind the Majority of Diseases This Century?

Richard Seargent by Richard Seargent
January 25, 2023
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Are Seed Oils Behind the Majority of Diseases This Century?
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What are the commonalities between heart disease, cancers, stroke, high blood pressure and diabetes, as well as obesity, metabolic syndromes, Alzheimer’s disease and other chronic conditions in modern society? All of them have seen dramatic increases in the last decade. They are all related to the use of seed oils.

In a speech given at the Sheraton Denver Downtown Hotel entitled “Diseases of Civilization? Are Seed Oil Excesses The Unifying Mechanism?” Dr. Chris Knobbe presented startling evidence to show that today’s chronic ailments are caused by seed oils.1

Knobbe, an optometrist, founded the non-profit Cure AMD Foundation to prevent vision loss from AMD.2He was formerly an associate clinical professor emeritus at the University of Texas Southwestern Medical Center.3

According to his research, the main unifying factor in the degenerative diseases and chronic conditions of modern society is the high intake of omega-6 oil in our daily diets. He describes the inundation with harmful oils from Western diets as “a global human experiment…without informed consent”.

The Rise of Polyunsaturated Fatty Acids, (PUFAs),

Trans fats are also known as polyunsaturated oil fatty acids (PUFAs) and can be found in vegetable oils. These include sunflower, cottonseed and rice bran. soybeanCorn, soybeans and other oils. “Roller mill tech” was the technology that replaced stone mill technology in grinding wheat into flour around 1880.4

The use of roller mill technology enabled the complete removal of bran and germ from a grain. This left only the endosperm which is a refined product that has had its nutrients removed.5Knobbe wrote the following on the Cure AMD Foundation site:6

“The first of these [PUFAs]Cottonseed oil. Soon after, partial and full hydrogenation of cottonseed oil was done. This resulted in the first ever artificially produced trans-fat. The latter was introduced by Proctor & Gamble in 1911 under the name ‘Crisco,’ which was marketed as ‘the healthier alternative to lard … and more economical than butter.'”

Crisco, which was the first commercially produced PUFAs (or trans fats), is still widely available today. Knobbe says that vegetable oil producers had a plan to replace higher-priced animal fats by underselling them.7The plan worked.

PUFAs are so well-liked that they now comprise 63% of American diet.8Knobbe says that in 1909 Americans consumed 2 grams of vegetable oil per day. But by 2010, Americans were eating an astonishing 80 grams of vegetable oil per day.9

Knobbe explains that there are several reasons PUFAs could be dangerous. They are not as nutritious as animal fats. They are responsible for most chronic diseases that modern society has created. PUFAs contribute to obesity. Knobbe estimates that Americans now consume 80g of PUFAs each day. That’s equivalent to 720 calories. It also means that more than a third of the calories they consume are “coming from factories.”10

PUFAs Help Chronic Diseases Rise

Many people are aware of the fact that conditions such as diabetes, obesity and heart disease were less prevalent in the 20th century. These conditions are more common than people realize. Knobbe says:11

  • In 1900, 12.5% of Americans died from heart disease. This number was 32% in 2010.
  • In 1811 1 in 118 people died of cancer. In 2010, 1 in 3 people died of cancer.
  • Type 2 Diabetes has seen a 25-fold increase in incidence over the past 80 years.
  • 1.2% of Americans were obese in the 19th century; by 2015, it was 39.8%
  • In 1930, there were only 50 cases of macular disease; by 2020, there are 196 millions.

Is it possible that the rise in chronic conditions is related to the increase in dietary intake of PUFAs. In his lecture, Knobbe says that it is. He offers the following explanation:12

These disorders, which range from heart disease to atherosclerosis and type-2 diabetes to macular damage and cancer, all share the same thing. They all have mitochondrial dysfunction …The very first thing that happens when the electron transport chain fails … is that it starts shooting out reactive oxygen species — these are hydroxyl radicals and superoxide …

These free radicals cause nuclear mitochondrial DNA modifications… which can contribute to heart failure, macular Degeneration, Alzheimer’s and Parkinson’s…a devastating lipid peroxidation cascade [that]This leads to toxic aldehydes.

Linoleic acid is an 18-carbon, omega-6 fat that is responsible for the biochemical reactions in seed oils. Linoleic acid, which accounts for around 80% of vegetable oils, is the primary fatty acids found in PUFAs. To avoid being harmful, omega-6 fats should be balanced with Omega-3 fats.

Knobbe says that most of the linoleic acids, when they oxidize, develop lipid hydroperoxides. These then rapidly degenerate to… oxidized Linoleic Acid metabolites.13

The oxidized-linoleic acid metabolisms are a dangerous combination. Knobbe states that they are cytotoxic. They can cause strokes or clots, and their atherosclerosis- and thrombogenic actions may be particularly alarming.

Insulin resistance is created by PUFAs

Diabetes, insulin resistanceSince the U.S. diet was based on PUFAs, metabolic syndrome has become a major problem. Nearly 70% of Americans are currently affected by metabolic syndrome. overweightA large number of people are obese or metabolically unwell.14

This increases the risk of developing Type 2 diabetes and other chronic conditions such as cancer or Alzheimer’s. Knobbe discusses how these conditions can develop in his lecture15

“When you consume omega-6 to excess … it combines with reactive oxygen species like hydroxyl radicals … so this begins catastrophic lipid peroxidation cascade — these polyunsaturated fats are accumulating [in]Your cells accumulate in your membranes and accumulate in your mitochondria, which causes a peroxidation reaction.

Knobbe says that the presence of so many reactive oxygen compounds can cause insulin resistance at a cellular level, and the production or lipid droplets in your liver.

“… that creates a catastrophic lipid part or it feeds back to the lipid peroxidation … so now you’re not burning fat for fuel properly so the person gaining weight and getting sick in this regard is now carb dependent — their glycolysis is working but … [they]Stop storing fat… it leads to obesity.”

This is especially true of Linoleic acid, according to Dr. Paul Saladino (a physician journalist) in a podcast. Linoleic acid “breaks the sensitivity for insulin at the level of your fat cells” — it makes them more insulin sensitive — and, since your fat cells control the insulin sensitivity of the rest of your body by releasing free fatty acids, you end up with insulin resistance.

Rat Studies and Indigenous People Identify PUFA Harm

Animal studies have clearly shown the harmful effects of PUFAs. Knobbe points out that two groups of rats were given identical diets. One group was fed 5% cottonseed oil, while the other had 1.5% butterfat.16The study result was:17

“… rats fed cottonseed oils grow to sixty per cent of their normal size.[d]On average they live for 555 days. They are fragile, weak and sickly little rats. They are healthier than rats fed butterfat; they reach normal size and live for 1020 days, so they can almost double their size. [of the cottonseed oil-fed rats]They live twice as long, and are infinitely healthier.

Knobbe asserts that although it might be suggested by the American Heart Association and other medical associations to discount such studies, possibly calling them paradoxical. However, there are examples of positive effects saturated and animal-based oil fats have on human health.

Tokelau, for example, is a group of people living on South Pacific islands between Hawaii, Australia and the South Pacific. They eat a diet that almost exclusively consists of coconut, fish and starchy tubers.18Knobbe notes that coconut oil contains saturated fat and accounts for between 54%-62% of their calories.

A study of Tokelau men aged between 40 and 69 found that they did not have any heart attacks, obesity, or diabetes.19Knobbe said they were “fantastically well”.

Knobbe says that at least 80% obesity and other chronic diseases in Westernized nations are caused by processed foods. Knobbe’s studies can be used to study animals or people not from Westernized countries. “It’s driven by vegetable oils as well as trans-fats… almost all fast food restaurants use soybean oil or canola oil.”

Knobbe’s opinion is shared by other experts

In my previous newsletter, I mentioned how Nina Teicholz (journalist) and Saladino both decry the popularity. PUFAs in the modern food systemBelief in the healthful benefits saturated fats can bring to your body.

Saladino and Teicholz talk about the history and demonizations of saturated fat and cholesterol. This began with the false hypothesis that saturated fat causes heart disease in 1960 and 1961.

The first Dietary Guidelines for Americans was introduced in 1980 to support the hypothesis. It advised people to reduce their intake of saturated fat and cholesterol while exempting carbs that were more high in PUFAs. It is not surprising that both the hypothesis and the dietary guidelines led to an increase in obesity and chronic diseases like heart disease.

Saladino & Teicholz discuss in the podcast the reasons this myth persists, despite scientific evidence.

Saturated animal fats could be recognized to be good for health processed industrial vegetable oilsIf grains and vegetable oils were made unsafe, this would devastate the major fast food and processed food industries that rely on them. Statin sales and other Big Pharma profit areas will also suffer. Big Food and Big Pharma have financial reasons to keep the health benefits of real foods hidden.

Knobbe is not alone. Experts believe that the huge increase in linoleic Acid consumption, due to its ubiquitous use in industrial vegetable oil and processed foods, is a major metabolic driver of obesity, cancer, and other chronic diseases.

They stress that the belief that high low-density lipoproteins (LDL) — the so-called “bad” cholesterol — are a risk factor for heart disease and that by lowering your LDL you lower your risk of a heart attack, is incorrect. They claim that science doesn’t support this. Because not all LDL particles behave the same, this is why it’s so surprising.

Saladino explained that LDL levels may fall if there is less red meat and saturated fat. However, these LDLs won’t be oxidized. It is the effect of LDL oxidation that triggers insulin resistance and related problems, including heart disease — something the LDL tests don’t detect.

Saladino states that eating saturated fat can raise your LDL but will not cause arterial damage.

Both doctors Knobbe & Saladino concluded that the majority of modern diseases are caused by seed oils and that it is best to get rid of them.



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Richard Seargent

Richard Seargent

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